Macrophage biology

International research group

Recommended literature

  1. Gordon,S. and P.R.Taylor. 2005. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5: 953-964.
  2. Burke,B. and C.E.Lewis. 2002. The Macrophage, Second Edition ed. Oxford University Press, Oxford.
  3. Gratchev,A., J.Kzhyshkowska, K.Kothe, I.Muller-Molinet, S.Kannookadan, J.Utikal, and S.Goerdt. 2006. Mphi1 and Mphi2 can be re-polarized by Th2 or Th1 cytokines, respectively, and respond to exogenous danger signals. Immunobiology 211: 473-486.
  4. Hansson,G.K. 2005. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J Med. 352: 1685-1695.
  5. Bingle,L., N.J.Brown, and C.E.Lewis. 2002. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196: 254-265.
  6. Stout,R.D. and J.Suttles. 2004. Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J. Leukoc. Biol. 76: 509-513.
  7. Gratchev,A., K.Schledzewski, P.Guillot, and S.Goerdt. 2001. Alternatively activated antigen-presenting cells: molecular repertoire, immune regulation, and healing. Skin Pharmacol. Appl. Skin Physiol 14: 272-279.
  8. Gordon,S., S.Clarke, D.Greaves, and A.Doyle. 1995. Molecular immunobiology of macrophages: recent progress. Curr. Opin. Immunol. 7: 24-33.
  9. Gratchev,A., P.Guillot, N.Hakiy, O.Politz, C.E.Orfanos, K.Schledzewski, and S.Goerdt. 2001. Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracellular matrix protein betaIG-H3. Scand. J. Immunol. 53: 386-392.
  10. Gordon,S. 2003. Alternative activation of macrophages. Nat. Rev. Immunol. 3: 23-35.
  11. Gratchev,A., J.Kzhyshkowska, J.Utikal, and S.Goerdt. 2005. Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages. Scand. J. Immunol. 61: 10-17.
  12. Kzhyshkowska,J., G.Workman, M.Cardo-Vila, W.Arap, R.Pasqualini, A.Gratchev, L.Krusell, S.Goerdt, and E.H.Sage. 2006. Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC. J. Immunol. 176: 5825-5832.
  13. Kzhyshkowska,J., S.Mamidi, A.Gratchev, E.Kremmer, C.Schmuttermaier, L.Krusell, G.Haus, J.Utikal, K.Schledzewski, J.Scholtze, and S.Goerdt. 2006. Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood 107: 3221-3228.
  14. Gratchev,A., J.Kzhyshkowska, S.Kannookadan, M.Ochsenreiter, A.Popova, X.Yu, S.Mamidi, E.Stonehouse-Usselmann, I.Muller-Molinet, L.Gooi, and S.Goerdt. 2008. Activation of a TGF-{beta}-Specific Multistep Gene Expression Program in Mature Macrophages Requires Glucocorticoid-Mediated Surface Expression of TGF-{beta} Receptor II. J. Immunol. 180: 6553-6565.
  15. Kzhyshkowska,J., A.Gratchev, C.Schmuttermaier, H.Brundiers, L.Krusell, S.Mamidi, J.Zhang, G.Workman, E.H.Sage, C.Anderle, P.Sedlmayr, and S.Goerdt. 2008. Alternatively Activated Macrophages Regulate Extracellular Levels of the Hormone Placental Lactogen via Receptor-Mediated Uptake and Transcytosis. J. Immunol. 180: 3028-3037.
  16. Park,S.Y., M.Y.Jung, S.J.Lee, K.B.Kang, A.Gratchev, V.Riabov, J.Kzhyshkowska, and I.S.Kim. 2009. Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages. J. Cell Sci. 122: 3365-3373.
  17. Zhang,J., A.Gratchev, V.Riabov, S.Mamidi, C.Schmuttermaier, L.Krusell, E.Kremmer, G.Workman, E.H.Sage, S.Jalkanen, S.Goerdt, and J.Kzhyshkowska. 2009. A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1. Mol. Cell Biol. 29: 6097-6105.
  18. Mosig,S., K.Rennert, S.Krause, J.Kzhyshkowska, K.Neunubel, R.Heller, and H.Funke. 2009. Different functions of monocyte subsets in familial hypercholesterolemia: potential function of CD14+ CD16+ monocytes in detoxification of oxidized LDL. FASEB J. 23: 866-874.

 


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