Macrophage biology

International research group


  1. Gabrielyan ES, Panosyan AG, Lebedeva MN, Akopov CE, Orekhov AN, Tertov VV, Hashimov HA, N-[(4-oxy-3-metoxy]benzidilen)benzilamin, for reduction of cholestirin levels and inhibition of platelets aggregation. Patent USSR N 1410457, 22.09.1986.
  2. Orekhov AN, Dobrotvorky AE. Drug for prophylaxis of atherosclerosis. Patent N 2082427, 27.06.1997.
  3. Orekhov AN. Drug “Karinat” for the prophylaxis of cardiovascular and oncologic diseases. Patent N 2129874, 10.05.1999.
  4. Orekhov AN. Drug for prolongation of the efficacy of garlic pulver. Patent №2141828, 27.11.1999.
  5. Bespalov BG, Barash NU, Ivanova OA, Krzivitsky PI, Semiglazov VF, Alexandrov VA, Orekhov AN, Sobenin IA. Method for mastopathy treatment. Patent №2266400, 10.04.2003.
  6. Kzhyshkowska J, Kremmer E, Goerdt S.”GL008 is a novel human macrophage putative chemokine upregulated by Th2 cytokines and corticoids in donor-dependent manner”. PCT-Application (international). No PCT/EP2005/008646. Applicant GSF-Forschungsz. f. Umwelt u. Gesundh., GmbH.


  1. Chazov,E.I., V.V.Tertov, A.N.Orekhov, A.A.Lyakishev, N.V.Perova, K.A.Kurdanov, K.A.Khashimov, I.D.Novikov, and V.N.Smirnov. 1986. Atherogenicity of blood serum from patients with coronary heart disease. Lancet 2: 595-598.
  2. Orekhov,A.N., E.R.Andreeva, A.V.Krushinsky, I.D.Novikov, V.V.Tertov, G.V.Nestaiko, K.Khashimov, V.S.Repin, and V.N.Smirnov. 1986. Intimal cells and atherosclerosis. Relationship between the number of intimal cells and major manifestations of atherosclerosis in the human aorta. Am. J. Pathol. 125: 402-415.
  3. Glukhova,M.A., A.E.Kabakov, M.G.Frid, O.I.Ornatsky, A.M.Belkin, D.N.Mukhin, A.N.Orekhov, V.E.Koteliansky, and V.N.Smirnov. 1988. Modulation of human aorta smooth muscle cell phenotype: a study of muscle-specific variants of vinculin, caldesmon, and actin expression. Proc. Natl. Acad. Sci. U. S. A 85: 9542-9546.
  4. Orekhov,A.N., V.V.Tertov, S.N.Pokrovsky, I.Y.Adamova, O.N.Martsenyuk, A.A.Lyakishev, and V.N.Smirnov. 1988. Blood serum atherogenicity associated with coronary atherosclerosis. Evidence for nonlipid factor providing atherogenicity of low-density lipoproteins and an approach to its elimination. Circ. Res. 62: 421-429.
  5. Orekhov,A.N. 1990. In vitro models of anti-atherosclerotic effects of cardiovascular drugs. Am. J. Cardiol. 66: 23I-28I.
  6. Orekhov,A.N., V.V.Tertov, A.E.Kabakov, I.Y.Adamova, S.N.Pokrovsky, and V.N.Smirnov. 1991. Autoantibodies against modified low density lipoprotein. Nonlipid factor of blood plasma that stimulates foam cell formation. Arterioscler. Thromb. 11: 316-326.
  7. Orekhov,A.N., V.V.Tertov, I.A.Sobenin, V.N.Smirnov, D.P.Via, J.Guevara, Jr., A.M.Gotto, Jr., and J.D.Morrisett. 1992. Sialic acid content of human low density lipoproteins affects their interaction with cell receptors and intracellular lipid accumulation. J. Lipid Res. 33: 805-817.
  8. Tertov,V.V., A.N.Orekhov, I.A.Sobenin, Z.A.Gabbasov, E.G.Popov, A.A.Yaroslavov, and V.N.Smirnov. 1992. Three types of naturally occurring modified lipoproteins induce intracellular lipid accumulation due to lipoprotein aggregation. Circ. Res. 71: 218-228.
  9. Tertov,V.V., I.A.Sobenin, Z.A.Gabbasov, E.G.Popov, O.Jaakkola, T.Solakivi, T.Nikkari, V.N.Smirnov, and A.N.Orekhov. 1992. Multiple-modified desialylated low density lipoproteins that cause intracellular lipid accumulation. Isolation, fractionation and characterization. Lab Invest 67: 665-675.
  10. Orekhov,A.N. and J.Grunwald. 1997. Effects of garlic on atherosclerosis. Nutrition 13: 656-663.
  11. Tertov,V.V., V.V.Kaplun, I.A.Sobenin, E.Y.Boytsova, N.V.Bovin, and A.N.Orekhov. 2001. Human plasma trans-sialidase causes atherogenic modification of low density lipoprotein. Atherosclerosis 159: 103-115.
  12. Kzhyshkowska,J., A.Gratchev, H.Brundiers, S.Mamidi, L.Krusell, and S.Goerdt. 2005. Phosphatidylinositide 3-kinase activity is required for stabilin-1-mediated endosomal transport of acLDL. Immunobiology 210: 161-173.
  13. Kzhyshkowska,J., G.Workman, M.Cardo-Vila, W.Arap, R.Pasqualini, A.Gratchev, L.Krusell, S.Goerdt, and E.H.Sage. 2006. Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC. J. Immunol. 176: 5825-5832.
  14. Kzhyshkowska,J., S.Mamidi, A.Gratchev, E.Kremmer, C.Schmuttermaier, L.Krusell, G.Haus, J.Utikal, K.Schledzewski, J.Scholtze, and S.Goerdt. 2006. Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood 107: 3221-3228.
  15. Martens,J.H., J.Kzhyshkowska, M.Falkowski-Hansen, K.Schledzewski, A.Gratchev, U.Mansmann, C.Schmuttermaier, E.Dippel, W.Koenen, F.Riedel, M.Sankala, K.Tryggvason, L.Kobzik, G.Moldenhauer, B.Arnold, and S.Goerdt. 2006. Differential expression of a gene signature for scavenger/lectin receptors by endothelial cells and macrophages in human lymph node sinuses, the primary sites of regional metastasis. J. Pathol. 208: 574-589.
  16. Gratchev,A., J.Kzhyshkowska, S.Kannookadan, M.Ochsenreiter, A.Popova, X.Yu, S.Mamidi, E.Stonehouse-Usselmann, I.Muller-Molinet, L.Gooi, and S.Goerdt. 2008. Activation of a TGF-{beta}-Specific Multistep Gene Expression Program in Mature Macrophages Requires Glucocorticoid-Mediated Surface Expression of TGF-{beta} Receptor II. J. Immunol. 180: 6553-6565.
  17. Sobenin,I.A., I.V.Andrianova, O.N.Demidova, T.Gorchakova, and A.N.Orekhov. 2008. Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study. J. Atheroscler. Thromb. 15: 334-338.
  18. Sobenin,I.A., L.V.Nedosugova, L.V.Filatova, M.I.Balabolkin, T.V.Gorchakova, and A.N.Orekhov. 2008. Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study. Acta Diabetol. 45: 1-6.
  19. Kzhyshkowska,J., A.Gratchev, C.Schmuttermaier, H.Brundiers, L.Krusell, S.Mamidi, J.Zhang, G.Workman, E.H.Sage, C.Anderle, P.Sedlmayr, and S.Goerdt. 2008. Alternatively Activated Macrophages Regulate Extracellular Levels of the Hormone Placental Lactogen via Receptor-Mediated Uptake and Transcytosis. J. Immunol. 180: 3028-3037.
  20. Aksenov,D.V., L.A.Medvedeva, T.A.Skalbe, I.A.Sobenin, V.V.Tertov, Z.A.Gabbasov, E.V.Popov, and A.N.Orekhov. 2008. Deglycosylation of apo B-containing lipoproteins increase their ability to aggregate and to promote intracellular cholesterol accumulation in vitro. Arch. Physiol Biochem. 114: 349-356.
  21. Park,S.Y., M.Y.Jung, S.J.Lee, K.B.Kang, A.Gratchev, V.Riabov, J.Kzhyshkowska, and I.S.Kim. 2009. Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages. J. Cell Sci. 122: 3365-3373.
  22. Zhang,J., A.Gratchev, V.Riabov, S.Mamidi, C.Schmuttermaier, L.Krusell, E.Kremmer, G.Workman, E.H.Sage, S.Jalkanen, S.Goerdt, and J.Kzhyshkowska. 2009. A novel GGA-binding site is required for intracellular sorting mediated by stabilin-1. Mol. Cell Biol. 29: 6097-6105.
  23. Sazonova,M., E.Budnikov, Z.Khasanova, I.Sobenin, A.Postnov, and A.Orekhov. 2009. Studies of the human aortic intima by a direct quantitative assay of mutant alleles in the mitochondrial genome. Atherosclerosis 204: 184-190.